At CO we don't fly RIO out of EWR anymore but we do fly GRU which is right next door. It is by far our second or third most senior trip. It's a solid 20 hour, Int'l paid 2day, and the best part about is we can piggy back those trips. A lot of people commute in the night of the trip, it departs around midnight and gets to GRU in the early AM. They have day rest and then work the flight back that night and arrive around 6am. So most people take advantage of that and go to there crash paid and get quite a bit of rest and fly back out that night to GRU. I have a friend who flys 6-8 of those a month and gets them done in 10 days or less and have a BAGGIN! PAY CHECK!
If you guys are about the money and not the layover, you want the layover to be short! I'm a money man, I'll see RIO on my own time...